The original paper is in English. Non-English content has been machine-translated and may contain typographical errors or mistranslations. ex. Some numerals are expressed as "XNUMX".
Copyrights notice
The original paper is in English. Non-English content has been machine-translated and may contain typographical errors or mistranslations. Copyrights notice
Apabila kita menggunakan Peranti Mikrobendalir Boleh Aturcara (PMD), kita perlu mencuci beberapa kawasan yang tercemar untuk menggunakan cip untuk eksperimen selanjutnya. Baru-baru ini, teknik mencuci baru yang dipanggil Block-Flushing telah dicadangkan. Block-Flushing mencuci kawasan tercemar di PMD dengan menggunakan aliran penimbal. Dalam Block-Flushing, kita perlu mengekalkan aliran penimbal dari port input ke port output PMD untuk tempoh yang lama untuk melarutkan sisa bahan cemar. Oleh itu, kita mungkin memerlukan banyak cecair penampan dan masa mencuci walaupun kawasan yang tercemar adalah kecil. Satu lagi kelemahan kaedah pencucian dengan Block-Flushing ialah kita mungkin tidak dapat membersihkan sisa bahan cemar pada injap sepenuhnya dengan hanya aliran penimbal. Untuk menangani isu-isu yang disebutkan di atas, kertas kerja ini mencadangkan idea yang sama sekali baru untuk mencuci PMD; kaedah kami tidak menggunakan aliran penimbal, tetapi membasuh kawasan yang tercemar dengan menggunakan pengadun. Dengan menggunakan pengadun, kita boleh melarutkan sisa bahan cemar pada injap di kawasan pengadun dengan sangat cekap. Dalam kertas ini, kami mencadangkan dua kaedah untuk mencuci PMD dengan menggunakan pengadun. Kaedah pertama boleh membasuh keseluruhan kawasan cip dengan menggunakan hanya empat kali daripada masa pengadun 2x2 tunggal. Kami juga mencadangkan kaedah kedua iaitu heuristik untuk mengurangkan bilangan injap yang bergerak kerana injap mungkin haus jika digunakan berkali-kali. Kami juga menunjukkan beberapa keputusan percubaan untuk mengesahkan bahawa kaedah kedua sememangnya boleh mengurangkan bilangan injap yang digunakan.
Yifang BAO
KuanDeng (Beijing) Science And Technology Ltd.
Shigeru YAMASHITA
Ritsumeikan University
Bing LI
Technical University of Munich
Tsung-Yi HO
the Department of Computer Science of National Tsing Hua University
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Salinan
Yifang BAO, Shigeru YAMASHITA, Bing LI, Tsung-Yi HO, "Mixer-Based Washing Methods for Programmable Microfluidic Devices" in IEICE TRANSACTIONS on Fundamentals,
vol. E105-A, no. 10, pp. 1385-1391, October 2022, doi: 10.1587/transfun.2021EAP1114.
Abstract: When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.
URL: https://global.ieice.org/en_transactions/fundamentals/10.1587/transfun.2021EAP1114/_p
Salinan
@ARTICLE{e105-a_10_1385,
author={Yifang BAO, Shigeru YAMASHITA, Bing LI, Tsung-Yi HO, },
journal={IEICE TRANSACTIONS on Fundamentals},
title={Mixer-Based Washing Methods for Programmable Microfluidic Devices},
year={2022},
volume={E105-A},
number={10},
pages={1385-1391},
abstract={When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.},
keywords={},
doi={10.1587/transfun.2021EAP1114},
ISSN={1745-1337},
month={October},}
Salinan
TY - JOUR
TI - Mixer-Based Washing Methods for Programmable Microfluidic Devices
T2 - IEICE TRANSACTIONS on Fundamentals
SP - 1385
EP - 1391
AU - Yifang BAO
AU - Shigeru YAMASHITA
AU - Bing LI
AU - Tsung-Yi HO
PY - 2022
DO - 10.1587/transfun.2021EAP1114
JO - IEICE TRANSACTIONS on Fundamentals
SN - 1745-1337
VL - E105-A
IS - 10
JA - IEICE TRANSACTIONS on Fundamentals
Y1 - October 2022
AB - When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.
ER -